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Science 13 January 1978:
Vol. 199. no. 4325, pp. 181 - 183
DOI: 10.1126/science.619449
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Articles

Science, Vol 199, Issue 4325, 181-183
Copyright © 1978 by American Association for the Advancement of Science

articles

Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation

JE Piletz and RE Ganschow

The inability of nursing pups to survive on milk of mice homozygous for the recessive mutation, lethal milk (lm), is correlated with a reduction in zinc levels of both milk and pup carcass. Administration of zinc to pups nursing on lmlm dams reduces the observed mortality and morbidity. It is suggested that lm alters zinc transport from maternal blood to milk and that its study may provide useful information for understanding the rare human disease, acrodermatitis enteropathica.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Identification of a Mutation in SLC30A2 (ZnT-2) in Women with Low Milk Zinc Concentration That Results in Transient Neonatal Zinc Deficiency.
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The Adaptive Response to Dietary Zinc in Mice Involves the Differential Cellular Localization and Zinc Regulation of the Zinc Transporters ZIP4 and ZIP5.
J. Dufner-Beattie, Y.-M. Kuo, J. Gitschier, and G. K. Andrews (2004)
J. Biol. Chem. 279, 49082-49090
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ZnT7, a Novel Mammalian Zinc Transporter, Accumulates Zinc in the Golgi Apparatus.
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J. Biol. Chem. 278, 4096-4102
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Zinc Transporters in the Rat Mammary Gland Respond to Marginal Zinc and Vitamin A Intakes during Lactation.
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J. Nutr. 132, 3280-3285
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Functional Characterization of a Novel Mammalian Zinc Transporter, ZnT6.
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J. Biol. Chem. 277, 26389-26395
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Differential Regulation of Zinc Transporter 1, 2, and 4 mRNA Expression by Dietary Zinc in Rats.
J. P. Liuzzi, R. K. Blanchard, and R. J. Cousins (2001)
J. Nutr. 131, 46-52
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Human Zinc Deficiency.
M. Hambidge (2000)
J. Nutr. 130, 1344S-1349
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Integrative Aspects of Zinc Transporters.
R. J. Cousins and R. J. McMahon (2000)
J. Nutr. 130, 1384S-1387
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Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells.
C. Murgia, I. Vespignani, J. Cerase, F. Nobili, and G. Perozzi (1999)
Am J Physiol Gastrointest Liver Physiol 277, G1231-G1239
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Zinc Deficiency in a Premature Infant Fed Exclusively Human Milk.
P. H. PARKER, G. L. HELINEK, R. L. MENEELY, F. K. GHISHAN, and H. L. GREENE (1982)
Arch Pediatr Adolesc Med 136, 77-78
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Trace Elements in the Fetus and Young Infant: I. Zinc.
J. C. L. Shaw (1979)
Arch Pediatr Adolesc Med 133, 1260-1268
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Science. ISSN 0036-8075 (print), 1095-9203 (online)