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Science 13 January 1978:
Vol. 199. no. 4325, pp. 146 - 152
DOI: 10.1126/science.22932
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Articles

Science, Vol 199, Issue 4325, 146-152
Copyright © 1978 by American Association for the Advancement of Science

articles

Phosphorylated proteins as physiological effectors

P Greengard

A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP. These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.


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Persistent phosphorylation parallels long-term desensitization of cerebellar purkinje cell AMPA-type glutamate receptors..
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Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPbeta.
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The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.
R. Llinas (1988)
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Light-induced phosphorylation of retina-specific polypeptides of Drosophila in vivo.
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Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation.
F Purrello, D. Burnham, and I. Goldfine (1983)
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{alpha}-Adrenergic Receptor Function in Schizophrenia: Receptor Number, Cyclic Adenosine Monophosphate Production, Adenylate Cyclase Activity, and Effect of Drugs.
M. S. Kafka and D. P. van Kammen (1983)
Arch Gen Psychiatry 40, 264-270
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Protein kinase injection reduces voltage-dependent potassium currents.
D. Alkon, J Acosta-Urquidi, J Olds, G Kuzma, and J. Neary (1983)
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Bilirubin-induced modulation of cerebral protein phosphorylation in neonate rabbits in vivo.
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Light-induced modification of Drosophila retinal polypeptides in vivo.
H Matsumoto, J. O'Tousa, and W. Pak (1982)
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Corticosterone increases the amount of protein 1, a neuron-specific phosphoprotein, in rat hippocampus.
E. Nestler, T. Rainbow, B. McEwen, and P Greengard (1981)
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Calmodulin plays a pivotal role in cellular regulation.
W. Cheung (1980)
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Is Polyoma Virus Middle T Antigen a Protein Kinase?.
A. E. Smith, M. Fried, Y. Ito, N. Spurr, and R. Smith (1980)
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T Antigens of SV40-transformed Cells.
F. McCormick, F. Chaudry, R. Harvey, R. Smith, P. W. J. Rigby, E. Paucha, and A. E. Smith (1980)
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Expression of the src-gene Product, pp60src, in Transformed and Reverted Mammalian Cells Infected with Avian Sarcoma Virus.
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Phosphorylation of Isocitrate dehydrogenase of Escherichia coli.
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Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 28 Is Mediated by MSK1.
S. Zhong, C. Jansen, Q.-B. She, H. Goto, M. Inagaki, A. M. Bode, W.-Y. Ma, and Z. Dong (2001)
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