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Science 6 January 1978:
Vol. 199. no. 4324, pp. 90 - 91
DOI: 10.1126/science.199.4324.90
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Articles

Phenobarbital: Effects of Long-Term Administration on Behavior and Brain of Artificially Reared Rats

JAIME DIAZ 1 and RICHARD J. SCHAIN 2

1 Department of Psychiatry, University of California, Los Angeles 90024
2 Department of Pediatrics, Neurology, and Psychiatry, University of California Los Angeles 90024

Two doses of phenobarbital were given daily for 2 weeks to infant rats fed by intragastric cannulas. The larger dose (60 milligrams per kilogram of body weight) resulted in decreased spontaneous activity and increased responses to novel stimuli. The smaller dose (15 milligrams per kilogram) resulted in increased spontaneous activity and also an increase of responses to novel stimuli. The larger dose produced a 12 percent reduction in brain growth, while the smaller dose was associated with a 3 percent reduction in brain growth.

Submitted on April 6, 1977
Revised on July 12, 1977


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