Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 January 1978:
Vol. 199. no. 4324, pp. 69 - 70
DOI: 10.1126/science.199.4324.69
Prev | Table of Contents | Next

Articles

Genetic Defect in Biosynthesis of the Precursor Form of the Fourth Component of Complement

ROBERT E. HALL 1 and HARVEY R. COLTEN 1

1 Ina Sue Perlmutter Cystic Fibrosis Center, Children's Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.

Submitted on July 21, 1977
Revised on October 4, 1977

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)