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Science 23 December 1977: Vol. 198. no. 4323, pp. 1264 - 1267 DOI: 10.1126/science.929199
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Articles
Science, Vol 198, Issue 4323, 1264-1267
Copyright © 1977 by American Association for the Advancement of Science
Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters
FF Jobsis
The relatively good transparency of biological materials in the near infrared region of the spectrum permits sufficient photon transmission through organs in situ for the monitoring of cellular events. Observations by infrared transillumination in the exposed heart and in the brain in cephalo without surgical intervention show that oxygen sufficiency for cytochrome a,a3, function, changes in tissue blood volume, and the average hemoglobin-oxyhemoglobin equilibrium can be recorded effectively and in continuous fashion for research and clinical purposes. The copper atom associated with heme a3 did not respond to anoxia and may be reduced under normoxic conditions, whereas the heme-a copper was at least partially reducible.
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