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Science 2 December 1977:
Vol. 198. no. 4320, pp. 930 - 931
DOI: 10.1126/science.337488
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Articles

Science, Vol 198, Issue 4320, 930-931
Copyright © 1977 by American Association for the Advancement of Science

articles

Somatostatin: widespread abnormality in tissues of spontaneously diabetic mice

YC Patel, DP Cameron, Y Stefan, F Malaisse-Lagae, and L Orci

Diabetic mice of the C57BL/6J obob and C57BL/Ks dbdb strains show a reduction in pancreatic somatostatin concentration accompanied in the obob strain by a striking decrease in the number of somatostatin-containing cells in the islets. Somatostatin concentration is also decreased in the stomach but increased in the hypothalamus. These findings suggest different control mechanisms for somatostatin in the hypothalamus compared to the gut and pancreas and exclude a primary genetic abnormality of somatostatin cells in the mutants.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Rat Pancreatic CCKB Receptor and Somatostatin Expression by Insulin.
S. Julien, J. Laine, and J. Morisset (2004)
Diabetes 53, 1526-1534
   Abstract »    Full Text »    PDF »
Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK.
K. A. Lacourse, L. J. Swanberg, P. J. Gillespie, J. F. Rehfeld, T. L. Saunders, and L. C. Samuelson (1999)
Am J Physiol Gastrointest Liver Physiol 276, G1302-G1309
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)