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Science 25 November 1977:
Vol. 198. no. 4319, pp. 851 - 852
DOI: 10.1126/science.199943
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Articles

Science, Vol 198, Issue 4319, 851-852
Copyright © 1977 by American Association for the Advancement of Science

articles

Cyclic nucleotides injected intracellularly into rat superior cervical ganglion cells

JP Gallagher and P Shinnick-Gallagher

Intracellular iontophoresis of either adenosine 3',5'-monophosphate or guanosine 3',5'-monophosphate produces a membrane depolarization and an increased membrane conductance in sympathetic ganglion cells of the rat superior cervical ganglion. Since adenosine 3',5'-monophosphate did not cause a membrane hyperpolarization, it is difficult to assign it a second messenger role in the mediation of the slow inhibitory postsynaptic potential. However, these results do not rule out the possibility that the cyclic nucleotides, at the intracellular concentrations attained in these experiments, participate in cellular processes that contribute to conductance changes which result in depolarization of the ganglion cell membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide.
M Kawatani, M Rutigliano, and W. de Groat (1985)
Science 229, 879-881
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Intracellular calcium measurements with arsenazo III during cyclic AMP injections into molluscan neurons.
P Hockberger and J. Connor (1983)
Science 219, 869-871
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Voltage-dependent calcium and potassium ion conductances: a contingency mechanism for an associative learning model.
D. Alkon (1979)
Science 205, 810-816
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Amorphous Semiconductors.
D. EMIN (1977)
Science 198, 881
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