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Science 25 November 1977:
Vol. 198. no. 4319, pp. 842 - 845
DOI: 10.1126/science.199942
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Articles

Science, Vol 198, Issue 4319, 842-845
Copyright © 1977 by American Association for the Advancement of Science

articles

Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?

YF Jacquet, WA Klee, KC Rice, I Iijima, and J Minamikawa

The unnatural (+) enantiomer of morphine had minimal activity in three opiate assays in vitro: the rat brain homogenate binding assay, the electrically stimulated guinea pig ileum assay, and the inhibition of adenylate cyclase in neuroblastoma X glioma hybrid cell homogenates. When (+)-morphine was microinfected into the periaqueductal gray (a site known to mediate morphine analgesia) of drug-naive rats, there was only minimal analgesia, but the hyperresponsivity usually observed after microinfection of (-)-morphine occurred. Also, when (+)-morphine was microinfected into the midbrain reticular formation of drug-naive rats, rotation similar to that following microinjection of (-)-morphine occurred. These behaviors were not blocked by naloxone. Significantly, they typically occur in precipitated abstinence in morphine-dependent rats. These observations suggest that there are at least two classes of receptors, one stereospecific and blocked by naloxone and the other only weakly stereospecific and not blocked by naloxone, and that precipitated abstinence may be due, in part, to a selective blockade of receptors of the former class but not of the latter.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Classification of opioids on the basis of change in seizure threshold in rats.
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Morphine-naloxone interactions: a role for nonspecific morphine excitatory effects in withdrawal.
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Basic and Clinical Studies of Endorphins.
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Dual Mechanism Mediating Opiate Effects?.
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