Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 November 1977:
Vol. 198. no. 4319, pp. 797 - 799
DOI: 10.1126/science.335511
Prev | Table of Contents | Next

Articles

Science, Vol 198, Issue 4319, 797-799
Copyright © 1977 by American Association for the Advancement of Science

articles

H-Y antigen and the genetics of sex determination

SS Wachtel

Widespread phylogenetic conservation of H-Y antigen indicates persistence of a vital function. It has been proposed that this function is the primary determination of mammalian sex. According to this proposal, the indifferent embryonic gonad is induced to differentiate as a testis in the presence of H-Y antigen, and as an ovary in the absence of H-Y antigen. But presence of H-Y antigen does not guarantee testicular differentiation. Other factors may be required: a gene that activates the H-Y structural locus, and another gene that codes for specific H-Y antigen receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
H-Y antigen gene loci.
F. Thompson (1978)
Science 201, 842
   PDF »
Genetic basis of XX male syndrome and XX true hermaphroditism: evidence in the dog.
J. Selden, S. Wachtel, G. Koo, M. Haskins, and D. Patterson (1978)
Science 201, 644-646
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)