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Science 18 November 1977:
Vol. 198. no. 4318, pp. 756 - 758
DOI: 10.1126/science.561998
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Articles

Science, Vol 198, Issue 4318, 756-758
Copyright © 1977 by American Association for the Advancement of Science

articles

Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli

RC Frederickson, V Burgis, and JD Edwards

A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of endogenous opioid peptides and may partly account for previous controversy over the direct action of naloxone in opiate-naive animals.


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