Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 November 1977:
Vol. 198. no. 4318, pp. 743 - 744
DOI: 10.1126/science.910158
Prev | Table of Contents | Next

Articles

Science, Vol 198, Issue 4318, 743-744
Copyright © 1977 by American Association for the Advancement of Science

articles

13-cis-Retinoic acid: inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

CJ Grubbs, RC Moon, RA Squire, GM Farrow, SF Stinson, DG Goodman, CC Brown, and MB Sporn

Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Preventive effects of Polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols.
R. A. Lubet, C. S. Yang, M.-J. Lee, Y. Hara, I. M. Kapetanovic, J. A. Crowell, V. E. Steele, M. M. Juliana, and C. J. Grubbs (2007)
Mol. Cancer Ther. 6, 2022-2028
   Abstract »    Full Text »    PDF »
4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin.
R. A. Lubet, K. Huebner, L. Y.Y. Fong, D. C. Altieri, V. E. Steele, L. Kopelovich, C. Kavanaugh, M.M. Juliana, S.-j. Soong, and C. J. Grubbs (2005)
Carcinogenesis 26, 571-578
   Abstract »    Full Text »    PDF »
Chemoprevention of Cancer - Focusing on Clinical Trials.
T. Kakizoe (2003)
Jpn. J. Clin. Oncol. 33, 421-442
   Abstract »    Full Text »    PDF »
Phase I Clinical Trial of Alitretinoin and Tamoxifen in Breast Cancer Patients: Toxicity, Pharmacokinetic, and Biomarker Evaluations.
J. A. Lawrence, P. C. Adamson, R. Caruso, C. Chow, D. Kleiner, R. F. Murphy, D. J. Venzon, M. Shovlin, M. Noone, M. Merino, et al. (2001)
J. Clin. Oncol. 19, 2754-2763
   Abstract »    Full Text »    PDF »
Celecoxib Inhibits N-Butyl-N-(4-hydroxybutyl)-nitrosamine-induced Urinary Bladder Cancers in Male B6D2F1 Mice and Female Fischer-344 Rats.
C. J. Grubbs, R. A. Lubet, A. T. Koki, K. M. Leahy, J. L. Masferrer, V. E. Steele, G. J. Kelloff, D. L. Hill, and K. Seibert (2000)
Cancer Res. 60, 5599-5602
   Abstract »    Full Text »
Asbestos-induced epithelial changes in organ cultures of hamster trachea: inhibition by retinyl methyl ether.
B. Mossman, J. Craighead, and B. MacPherson (1980)
Science 207, 311-313
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)