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Science 18 November 1977:
Vol. 198. no. 4318, pp. 739 - 741
DOI: 10.1126/science.71759
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Articles

Science, Vol 198, Issue 4318, 739-741
Copyright © 1977 by American Association for the Advancement of Science

articles

Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line

G Balaban-Malenbaum and F Gilbert

Four human neuroblastoma cell lines were studied by chromosome banding techniques. All of the lines contained a marker chromosome with a long nonbanding homogeneously staining region (HSR). The HSR-containing chromosome differed in each line. One line contained two classes of cells: one with an HST marker chromosome and the other with double minute chromosomes. Each cell had one of these abnormalities; no cell had both. The presence of two additional chromosomal markers in all cells of this line indicates a common origin. These observations suggest that the double minute chromosomes are derived from the HSR.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MYCN Gene Amplification : Identification of Cell Populations Containing Double Minutes andHomogeneously Staining Regions in Neuroblastoma Tumors.
M. Yoshimoto, S. R. Caminada de Toledo, E. M. Monteiro Caran, M. T. de Seixas, M. L. de Martino Lee, S. de Campos Vieira Abib, S. M. R. Vianna, S. T. Schettini, and J. Anderson Duffles Andrade (1999)
Am. J. Pathol. 155, 1439-1443
   Abstract »    Full Text »    PDF »
Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells.
R. T. Schimke, P. C. Brown, R. J. Kaufman, M. McGrogan, and D. L. Slate (1981)
Cold Spring Harb Symp Quant Biol 45, 785-797
   Abstract »    PDF »
Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain.
R. Kennett and F Gilbert (1979)
Science 203, 1120-1121
   Abstract »    PDF »


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