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Science 18 November 1977:
Vol. 198. no. 4318, pp. 726 - 727
DOI: 10.1126/science.198.4318.726
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Articles

Veatchine: Coexistence of Epimers in a Crystal Structure

WILSON H. DE CAMP 1 and S. WILLIAM PELLETIER 2

1 Institute for Natural Products Research, University of Georgia, Athens 30602
2 Institute for Natural Products Research and Department of Chemistry, University of Georgia

An x-ray crystal structure determination of veatchine, a C20-diterpenoid alkaloid, reveals the coexistence of molecules which differ in configuration at one of seven asymmetric carbon atoms. This disorder between epimers demonstrates the stability of both forms, and accounts for the doubling of certain peaks in the magnetic resonance spectra of this and related alkaloids.

Submitted on May 10, 1977
Revised on September 12, 1977

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Science. ISSN 0036-8075 (print), 1095-9203 (online)