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Science 11 November 1977:
Vol. 198. no. 4317, pp. 617 - 620
DOI: 10.1126/science.199941
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Articles

Science, Vol 198, Issue 4317, 617-620
Copyright © 1977 by American Association for the Advancement of Science

articles

Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine

JE Silva and PR Larsen

An excellent correlation was observed between nuclear triiodothyronine (T3) and the ensuing suppression of thyrotropin (TSH) after a single intravenous injection of T3 to thyroidectomized (hypothyroid) rats. At 1 and 2 hours after injection of thyroxine (T4), in amounts equally potent to the administered T3 in terms of acute suppression of TSH, the same quantities of T3 were found in the pituitary nuclei. Virtually no nuclear T4 was present, and plasma T3 was negligible at these short intervals after T4 injection. These results suggest that suppression of TSH release in hypothyroid rats occurs by interaction of T3 with the nuclear receptor of the thyrotroph. After T4 injection, the T3 found in the nucleus is derived from rapid intrapituitary monodeiodination.


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Type 2 Deiodinase Polymorphism (Threonine 92 Alanine) Predicts L-Thyroxine Dose to Achieve Target Thyrotropin Levels in Thyroidectomized Patients.
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Atypical Expression of Type 2 Iodothyronine Deiodinase in Thyrotrophs Explains the Thyroxine-Mediated Pituitary Thyrotropin Feedback Mechanism.
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A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.
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Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
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Cloning and Expression of the Chicken Type 2 Iodothyronine 5'-Deiodinase.
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Studies of the Hormonal Regulation of Type 2 5'-Iodothyronine Deiodinase Messenger Ribonucleic Acid in Pituitary Tumor Cells Using Semiquantitative Reverse Transcription-Polymerase Chain Reaction.
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Relationship of Serum T4 and T3 to TSH in Primary Hypothyroidism.
S. Ryder, G. M. Gollapudi, and A. Varma (1980)
Arch Intern Med 140, 1290-1291
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Thyroid hormone action at the cellular level.
J. Oppenheimer (1979)
Science 203, 971-979
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Hypertriiodothyroninemia in Hypothyroidism Treated With Thyroglobulin.
E. Morillo and L. I. Gardner (1979)
Arch Pediatr Adolesc Med 133, 71-72
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