Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 November 1977:
Vol. 198. no. 4317, pp. 569 - 574
DOI: 10.1126/science.144320
Prev | Table of Contents | Next

Articles

Science, Vol 198, Issue 4317, 569-574
Copyright © 1977 by American Association for the Advancement of Science

articles

Membrane adenosinetriphosphatase: a digitalis receptor?

T Akera

The enzyme Na+,K+-ATPase is a good model for receptor studies because of its known functional correlates. The binding of digitalis to the enzyme observed in vitro satisfied the criteria for receptor binding. Studies of the relationship between the digitalis binding and the drug action reveal an impressive correlation between these events but fail to provide proof of a causal relationship. Studies with other Na+,K+-ATPase inhibitors and agents that affect transmembrane Na+ movements (steps that would follow Na+,K+-ATPase inhibition) provide further supportive evidence that sodium pump inhibition and the resulting enhancement of intracellular Na+ transients cause the inotropic action of digitalis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Oleandrin Suppresses Activation of Nuclear Transcription Factor-{{kappa}}B, Activator Protein-1, and c-Jun NH2-Terminal Kinase.
S. K. Manna, N. K. Sah, R. A. Newman, A. Cisneros, and B. B. Aggarwal (2000)
Cancer Res. 60, 3838-3847
   Abstract »    Full Text »
Sodium Pump Isoforms in Xenotransplantation: Importance of Biochemical Compatibility.
A. M. Rose, H. M. Qazzaz, N. Zolotarjova, B. J. Mellett, A. W. Martin, and R. Valdes Jr (2000)
Clin. Chem. 46, 234-241
   Abstract »    Full Text »    PDF »
Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-kappa B Activation, Ikappa Balpha Phosphorylation, and Degradation.
M. M. Chaturvedi, A. Kumar, B. G. Darnay, G. B. N. Chainy, S. Agarwal, and B. B. Aggarwal (1997)
J. Biol. Chem. 272, 30129-30134
   Abstract »    Full Text »    PDF »
Modulation of Cytokine Production and Protection Against Lethal Endotoxemia by the Cardiac Glycoside Ouabain.
A. Matsumori, K. Ono, R. Nishio, H. Igata, B Pharm, T. Shioi, S. Matsui, Y. Furukawa, A. Iwasaki, Y. Nose, et al. (1997)
Circulation 96, 1501-1506
   Abstract »    Full Text »
Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum.
N Leblanc and Hume JR (1990)
Science 248, 372-376
   Abstract »    PDF »
Digitalis genin activity: side-group carbonyl oxygen position is a major determinant.
D. Fullerton, K Yoshioka, D. Rohrer, A. From, and K Ahmed (1979)
Science 205, 917-919
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)