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Science 4 November 1977:
Vol. 198. no. 4316, pp. 513 - 514
DOI: 10.1126/science.910143
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Articles

Science, Vol 198, Issue 4316, 513-514
Copyright © 1977 by American Association for the Advancement of Science

articles

DJ Hoffman, and SK Niyogi

Five metal salts (lead, cadmium, cobalt, copper, and manganese),which are mutagenic or carcinogenic, decreasing the fidelity of DNA synthesis in vitro, stimulated chain initiation of RNA synthesis at concentrations that inhibited overall RNA synthesis. In contrast, other metal salts (zinc, magnesium, lithium, sodium,and potassium) not in this category inhibited chain initiation of RNA synthesis at concentrations that inhibited overall RNA synthesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Survey of Metal-induced Mutagenicity in Vitro and in Vivo.
K. Hansen and R. M. Stern (1984)
International Journal of Toxicology 3, 381-430
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