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Science 4 November 1977:
Vol. 198. no. 4316, pp. 511 - 513
DOI: 10.1126/science.143718
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Articles

Science, Vol 198, Issue 4316, 511-513
Copyright © 1977 by American Association for the Advancement of Science

articles

Unilateral nephrectomy: effect on survival in NZB/NZW mice

MM Beyer, AD Steinberg, AD Nicastri, and EA Friedman

Male F1 New Zealand Black X New Zealand White mice, which spontaneously develop immune complex renal disease, underwent unilateral nephrectomy at 3 months of age and were compared with sham-operated controls. At 12 months of age only 24% of mice with a single kidney were alive, while 85% of sham-operated controls survived to the same age. Unilaterally nephrectomized mice had more severe renal histologic changes, as shown by light and immunofluorescence microscopy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lupus Nephritis.
J. E. BALOW, H. A. AUSTIN III, G. C. TSOKOS, T. T. ANTONOVYCH, A. D. STEINBERG, and J. H. KLIPPEL (1987)
Ann Intern Med 106, 79-94
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Dietary Protein Intake and Progressive Glomerular Sclerosis: The Role of Capillary Hypertension and Hyperperfusion in the Progression of Renal Disease.
T. W. MEYER, S. ANDERSON, and B. M. BRENNER (1983)
Ann Intern Med 98, 832-838
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