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Science 28 October 1977:
Vol. 198. no. 4315, pp. 414 - 415
DOI: 10.1126/science.410104
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Articles

Science, Vol 198, Issue 4315, 414-415
Copyright © 1977 by American Association for the Advancement of Science

articles

Thyrotropin-releasing hormone: abundance in the skin of the frog, Rana pipiens

IM Jackson and S Reichlin

Thyrotropin-releasing hormone, a hypothalamic tripeptide that stimulates the secretion of pituitary thyroid-stimulating hormone in mammalian species and is widely distributed throughout the brain of vertebrates, is present in the skin of the frog (Rana pipiens) in concentrations twice that found in the hypothalamus of this amphibian. A skin extract shows biologic activity appropriate to its immunoreactive content. Apart from the brain and spinal cord, immunoreactive thyrotropin-releasing hormone is found only in the blood and retina in significant concentrations. The results imply that frog skin is a huge endocrine organ that synthesizes and secretes this hormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thyrotropin-releasing hormone precursor: characterization in rat brain.
R. Lechan, P Wu, I. Jackson, H Wolf, S Cooperman, G Mandel, and R. Goodman (1986)
Science 231, 159-161
   Abstract »    PDF »
Immunohistochemical localization in the rat brain of the precursor for thyrotropin-releasing hormone.
I. Jackson, P Wu, and R. Lechan (1985)
Science 229, 1097-1099
   Abstract »    PDF »
Peptide Leucine Arginine, a Potent Immunomodulatory Peptide Isolated and Structurally Characterized from the Skin of the Northern Leopard Frog, Rana pipiens.
A. L. Salmon, L. J. M. Cross, A. E. Irvine, T. R. J. Lappin, M. Dathe, G. Krause, P. Canning, L. Thim, M. Beyermann, S. Rothemund, et al. (2001)
J. Biol. Chem. 276, 10145-10152
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)