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Science 21 October 1977:
Vol. 198. no. 4314, pp. 307 - 309
DOI: 10.1126/science.561997
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Articles

Science, Vol 198, Issue 4314, 307-309
Copyright © 1977 by American Association for the Advancement of Science

articles

Diazepam maintenance of alcohol preference during alcohol withdrawal

JA Deutsch and NY Walton

After forced intragastric intubation of alcohol, rats will show a greatly increased tendency to self-administer alcohol in a free-choice situation. Diazepam (Valium) dosage (5 milligrams per kilogram of body weight) during the period ow withdrawal serves to maintain undiminished such alcohol self-administration. Without such diazepam dosage the tendency to self-administer alcohol returns to control levels.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)