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Science 21 October 1977:
Vol. 198. no. 4314, pp. 300 - 302
DOI: 10.1126/science.333582
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Articles

Science, Vol 198, Issue 4314, 300-302
Copyright © 1977 by American Association for the Advancement of Science

articles

Gonadotropin-releasing hormone in milk

T Baram, Y Koch, E Hazum, and M Fridkin

The hypothalamic hormone gonadotropin-releasing hormone (GnRH) has been found in milk of man, cow, and rat. Radioimmunoassays of acidified milk indicate concentrations of GnRH ranging between 0.1 and 3 nanograms per milliliter. Multistep extractions, followed by electrophoresis, reveal gonadotropin-releasing activity in the fraction that comigrates with the GnRH-marker. A second hypothalamic hormone, thyrotropin-releasing hormone, is present in milk at a much lower concentration. "Milk -GnRH" may influence the secretion of the gonadotropic hormones in neonates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Gonadotropin-Releasing Hormone (GnRH) and GnRH Receptor Messenger Ribonucleic Acid Expression Patterns in Different Tissues of the Female Rat across the Estrous Cycle.
T. D. Schirman-Hildesheim, T. Bar, N. Ben-Aroya, and Y. Koch (2005)
Endocrinology 146, 3401-3408
   Abstract »    Full Text »    PDF »
Two Forms of Gonadotropin-releasing Hormone (GnRH) Are Expressed in Human Breast Tissue and Overexpressed in Breast Cancer: A Putative Mechanism for the Antiproliferative Effect of GnRH by Down-Regulation of Acidic Ribosomal Phosphoproteins P1 and P2.
A. Chen, E. Kaganovsky, S. Rahimipour, N. Ben-Aroya, E. Okon, and Y. Koch (2002)
Cancer Res. 62, 1036-1044
   Abstract »    Full Text »    PDF »
Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
R. J Playford, C. E Macdonald, and W. S Johnson (2000)
Am. J. Clinical Nutrition 72, 5-14
   Abstract »    Full Text »    PDF »
Selective Expression of Neuropeptides in the Rat Mammary Gland: Somatostatin Gene Is Expressed During Lactation.
A. Chen, O. Laskar-Levy, and Y. Koch (1999)
Endocrinology 140, 5915-5921
   Abstract »    Full Text »
Gonadotropin-releasing hormone binding sites in human breast carcinoma.
K. Eidne, C. Flanagan, and R. Millar (1985)
Science 229, 989-991
   Abstract »    PDF »
Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?.
E Loumaye, J Thorner, and K. Catt (1982)
Science 218, 1323-1325
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Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (mu) receptors?.
E Hazum, J. Sabatka, K. Chang, D. Brent, J. Findlay, and P Cuatrecasas (1981)
Science 213, 1010-1012
   Abstract »    PDF »
Premature Thelarche: Natural History and Etiologic Investigation.
J. L. Mills, P. D. Stolley, J. Davies, and T. Moshang Jr (1981)
Arch Pediatr Adolesc Med 135, 743-745
   Abstract »    PDF »


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