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Science 14 October 1977:
Vol. 198. no. 4313, pp. 199 - 201
DOI: 10.1126/science.905823
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Articles

Science, Vol 198, Issue 4313, 199-201
Copyright © 1977 by American Association for the Advancement of Science

articles

Bovine protoporphyria: the first nonhuman model of this hereditary photosensitizing disease

GR RUTH, S Schwartz, and B Stephenson

Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bovine Teat Atresia Associated with Horn Fly (Haematobia irritans irritans (L.))-induced Dermatitis.
J. F. Edwards, S. E. Wikse, R. W. Field, C. C. Hoelscher, and D. B. Herd (2000)
Vet. Pathol. 37, 360-364
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Science. ISSN 0036-8075 (print), 1095-9203 (online)