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Science 30 September 1977:
Vol. 197. no. 4311, pp. 1387 - 1389
DOI: 10.1126/science.897677
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Articles

Science, Vol 197, Issue 4311, 1387-1389
Copyright © 1977 by American Association for the Advancement of Science

articles

Brain self-stimulation: direct evidence for the involvement of dopamine in the prefrontal cortex

F Mora and RD Myers

Rats were trained to self-stimulate the medial prefrontal cortex, a region rich in dopaminergic terminals. After the region adjacent to the electrode site was labeled with [14C]dopamine, it was perfused repeatedly by means of push-pull cannulas. Electrical stimulation of this cortical area in six animals enhanced the release of dopamine and its associated metabolites in nine of 16 experiments. Thus in vivo evidence is provided that dopamine is involved in the brain self-stimulation mechanism within the frontal cortex.


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