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Science 30 September 1977:
Vol. 197. no. 4311, pp. 1376 - 1378
DOI: 10.1126/science.897674
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Articles

Science, Vol 197, Issue 4311, 1376-1378
Copyright © 1977 by American Association for the Advancement of Science

articles

Complexes of stannous fluoride and other group IVB dihalides with mammalian hemoproteins

AR Dahl and E Hodgson

Stannous fluoride, the widely used anticaries toothpaste additive, and other tin and germanium dihalides form complexes with hemoproteins such as hepatic cytochrome P-450, hemoglobin, and peroxidase. These complexes are characterized by visible spectra closely similar in shape, molar absorptivity, and absorbance maxima to those obtained with analogous complexes of carbon monoxide. Evidence is presented that the observed complexes are formed with uncharged MX2 or LMX2, moieties (where L is a neutral Lewis base, M is a metal, and X is a halogen) acting as pi-acceptor ligands.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction and inhibition of pesticide-metabolizing enzymes: roles in synergism of pesticides and pesticide action.
E. Hodgson (1999)
Toxicology and Industrial Health 15, 6-11
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