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Science 30 September 1977:
Vol. 197. no. 4311, pp. 1367 - 1369
DOI: 10.1126/science.197601
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Articles

Science, Vol 197, Issue 4311, 1367-1369
Copyright © 1977 by American Association for the Advancement of Science

articles

beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland

R Guillemin, T Vargo, J Rossier, S Minick, N Ling, C Rivier, W Vale, and F Bloom

The opiate-like peptide beta-endorphin and adrenocorticotropin are concomitantly secreted in increased amounts by the adenohypophysis in response to acute stress or long-term adrenalectomy as well as in vitro in response to purified corticotropin releasing factor and other secretagogues. Conversely, administration of the synthetic glucocorticoid dexamethasone inhibits the secretion of both adrenocorticotropin and beta-endorphin. Thus, both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin.


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