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Science 23 September 1977:
Vol. 197. no. 4310, pp. 1287 - 1288
DOI: 10.1126/science.897669
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Articles

Science, Vol 197, Issue 4310, 1287-1288
Copyright © 1977 by American Association for the Advancement of Science

articles

A method for detecting 8-methoxypsoralen in the ocular lens

S Lerman and RF Borkman

The use of 8-methoxypsoralen for treating psoriasis could prove hazardous if this photosensitizing agent enters the ocular lens. Phosphorescence spectra of intact rat lenses reveal concentrations of 8-methoxypsoralen on the order 10(-5)M after intraperitoneal injection of 8-methoxypsoralen. There is evidence that this drug can function as a photosensitizing agent, enhancing ultraviolet-induced changes within the lens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lenticular Psoralen Photoproducts and Cataracts of a PUVA-Treated Psoriatic Patient.
T. Y. Woo, R. C. Wong, J. M. Wong, T. F. Anderson, and S. Lerman (1985)
Arch Dermatol 121, 1307-1308
   Abstract »    PDF »
Long-term Risks of Psoralen and UV-A Therapy for Psoriasis.
E. M. Farber, E. A. Abel, and A. J. Cox (1983)
Arch Dermatol 119, 426-431
   Abstract »    PDF »


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