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Science 16 September 1977:
Vol. 197. no. 4309, pp. 1189 - 1191
DOI: 10.1126/science.897662
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Articles

Science, Vol 197, Issue 4309, 1189-1191
Copyright © 1977 by American Association for the Advancement of Science

articles

Competition of delta 9-tetrahydrocannabinol with estrogen in rat uterine estrogen receptor binding

AB Rawitch, GS Schultz, KE Ebner, and RM Vardaris

Direct competition experiments with delta 9 -tetrahydrocannibinol (delta 9-THC) and estradiol in binding assays with rat uterine cytosol estrogen receptors showed that delta 9-THC was a weak, but nevertheless significant, competitor for binding to cytoplasmic estrogen receptors. These data support, at the molecular level, the observations that delta 9-THC has a weak estrogenic activity (at least the ability to bind to estrogen receptors). Moreover, estrogen-like binding suggests that delta 9-THC, acting at the level of estrogen receptor, causes a primary estrogenic effect rather than an indirect or secondary phenomenon.


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Inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors?.
R. Smith, N. Besch, P. Besch, and C. Smith (1979)
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delta9-Tetrahydrocannabinol and 17beta-estradiol bind to different macromolecules in estrogen target tissues.
A. Okey and G. Bondy (1978)
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