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Science 16 September 1977:
Vol. 197. no. 4309, pp. 1181 - 1183
DOI: 10.1126/science.897660
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Articles

Science, Vol 197, Issue 4309, 1181-1183
Copyright © 1977 by American Association for the Advancement of Science

articles

Timekeeping by the pineal gland

S Binkley, JB Riebman, and KB Reilly

N-Acetyltransferase, an enzyme involved in melatonin production in the pineal gland, exhibits a circadian rhythm in chickens with peak values in the dark-time and low values during the light-time, commencing at lights-on. When pineal glands of chickens killed during the dark-time (with high N-acetyltransferase activity) were organ-cultured, there was a decline in enzyme activity to light-time values. Regardless of the time of the dark at which the chickens were killed, the enzyme activity reached light-time levels at precisely the same time.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Circadian clock in culture: N-acetyltransferase activity of chick pineal glands oscillates in vitro.
C. Kasal, M Menaker, and J. Perez-Polo (1979)
Science 203, 656-658
   Abstract »    PDF »
The pineal gland: a biological clock in vitro.
S. Binkley, J. Riebman, and K. Reilly (1978)
Science 202, 1198-1120
   Abstract »    PDF »


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