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Science 9 September 1977:
Vol. 197. no. 4308, pp. 1092 - 1094
DOI: 10.1126/science.887941

Articles

Science, Vol 197, Issue 4308, 1092-1094
Copyright © 1977 by American Association for the Advancement of Science


articles

Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs

MS Kaplan and JW Hinds

Three-month-old rats were injected intraperitoneally with [3H]thymidine (4.3 microcuries per gram of body weight) and allowed to survive for 30 days. Radioautography of 1-micrometer sections revealed labeled cells in the granular layers of dentate gyrus and olfactory bulb; these were confirmed as neurons by electron microscopy of reembedded 1-micrometer sections.


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Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus.
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Cyclic Nucleotide-Mediated Regulation of Hippocampal Mossy Fiber Development: A Target-Specific Guidance.
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Subunit Heterogeneity of Cytoplasmic Dynein: Differential Expression of 14 kDa Dynein Light Chains in Rat Hippocampus.
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Effects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus.
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Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat.
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D. R. Kornack and P. Rakic (2001)
PNAS 98, 4752-4757
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Comparative Views of Adult Neurogenesis.
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M. A. Gates, R. A. Fricker-Gates, S. S. Magavi, and J. D. Macklis (2000)
Neuroscientist 6, 326-337
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Neurogenesis in the Neocortex of Adult Primates.
E. Gould, A. J. Reeves, M. S. Graziano, and C. G. Gross (1999)
Science 286, 548-552
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Human Neuronal gamma -Aminobutyric AcidA Receptors: Coordinated Subunit mRNA Expression and Functional Correlates in Individual Dentate Granule Cells.
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J. Neurosci. 19, 8312-8318
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Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain.
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J. Neurosci. 19, 5990-6005
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Continuation of neurogenesis in the hippocampus of the adult macaque monkey.
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Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain.
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Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils.
J. Liu, K. Solway, R. O. Messing, and F. R. Sharp (1998)
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E. Gould, P. Tanapat, B. S. McEwen, G. Flugge, and E. Fuchs (1998)
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Experience-Dependent Modifications in MAP2 Phosphorylation in Rat Olfactory Bulb.
B. D. Philpot, J. H. Lim, S. Halpain, and P. C. Brunjes (1997)
J. Neurosci. 17, 9596-9604
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Olfactory Bulb Recovery after Early Sensory Deprivation.
D. M. Cummings, H. E. Henning, and P. C. Brunjes (1997)
J. Neurosci. 17, 7433-7440
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Genetic influence on neurogenesis in the dentate gyrus of adult mice.
G. Kempermann, H. G. Kuhn, and F. H. Gage (1997)
PNAS 94, 10409-10414
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Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain.
H. G. Kuhn, J. Winkler, G. Kempermann, L. J. Thal, and F. H. Gage (1997)
J. Neurosci. 17, 5820-5829
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Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus.
J. M. Parent, T. W. Yu, R. T. Leibowitz, D. H. Geschwind, R. S. Sloviter, and D. H. Lowenstein (1997)
J. Neurosci. 17, 3727-3738
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Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation.
E. Gould, B. S. McEwen, P. Tanapat, L. A. M. Galea, and E. Fuchs (1997)
J. Neurosci. 17, 2492-2498
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Human STX Polysialyltransferase Forms the Embryonic Form of the Neural Cell Adhesion Molecule. TISSUE-SPECIFIC EXPRESSION, NEURITE OUTGROWTH, AND CHROMOSOMAL LOCALIZATION IN COMPARISON WITH ANOTHER POLYSIALYLTRANSFERASE, PST.
K. Angata, J. Nakayama, B. Fredette, K. Chong, B. Ranscht, and M. Fukuda (1997)
J. Biol. Chem. 272, 7182-7190
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Expression of type 1 inositol 1,4,5-trisphosphate receptor during axogenesis and synaptic contact in the central and peripheral nervous system of developing rat.
M. Dent, G Raisman, and F. Lai (1996)
Development 122, 1029-1039
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Review : Neuronal Precursor Cells and Neurogenesis in the Adult Forebrain.
S. A. Goldman (1995)
Neuroscientist 1, 338-350
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Long-distance neuronal migration in the adult mammalian brain.
C Lois and A Alvarez-Buylla (1994)
Science 264, 1145-1148
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bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.
D. Merry, D. Veis, W. Hickey, and S. Korsmeyer (1994)
Development 120, 301-311
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Limits of neurogenesis in primates.
P Rakic (1985)
Science 227, 1054-1056
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Neurons generated in the adult brain are recruited into functional circuits.
J. Paton and F. Nottebohm (1984)
Science 225, 1046-1048
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Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life.
S. Bayer, J. Yackel, and P. Puri (1982)
Science 216, 890-892
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Opiates inhibit neurogenesis in the adult rat hippocampus.
A. J. Eisch, M. Barrot, C. A. Schad, D. W. Self, and E. J. Nestler (2000)
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E. Gould, N. Vail, M. Wagers, and C. G. Gross (2001)
PNAS 98, 10910-10917
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