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Science 9 September 1977:
Vol. 197. no. 4308, pp. 1079 - 1082
DOI: 10.1126/science.196336
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Articles

Science, Vol 197, Issue 4308, 1079-1082
Copyright © 1977 by American Association for the Advancement of Science

articles

Rous sarcomas in chickens: enhanced growth coexisting with concomitant immunity

RA McBride, DH Watanabe, and LW Schierman

Chickens bearing Rous sarcoma virus-induced tumors in one wing did not develop new tumors when subsequently inoculated with Rous sarcoma virus in the other wing. However, the second inoculation of Rous sarcoma virus caused accelerated growth of the established tumors. This phenomenon was found to be bursa-dependent. Paradoxically, established tumors in bursectomized chickens grew at a diminished rate if the chickens were reinoculated with Rous sarcoma virus.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)