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Science 2 September 1977:
Vol. 197. no. 4307, pp. 994 - 996
DOI: 10.1126/science.887938
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Articles

Science, Vol 197, Issue 4307, 994-996
Copyright © 1977 by American Association for the Advancement of Science

articles

Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids

S Hammarstrom, M Hamberg, EA Duell, MA Stawiski, TF Anderson, and JJ Voorhees

Psoriasis is a prototype of several common, glucocorticoid responsive, inflammatory proliferative skin diseases. Within 28 hours, glucocorticoid reduced the increased concentration of free arachidonic acid in diseased tissue. This reduction was observed prior to visible improvement of disease and may be an important molecular mechanism for the therapeutic efficacy of glucocorticoids in psoriasis and similar inflammatory diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Leukotrienes and Other Lipoxygenase Products in the Pathogenesis and Therapy of Psoriasis and Other Dermatoses.
J. J. Voorhees (1983)
Arch Dermatol 119, 541-547
   Abstract »    PDF »
Benoxaprofen Improves Psoriasis: A Double-blind Study.
K. Kragballe and T. Herlin (1983)
Arch Dermatol 119, 548-552
   Abstract »    PDF »
Commentary: Cyclic Adenosine Monophosphate Regulation of Normal and Psoriatic Epidermis.
J. J. Voorhees (1982)
Arch Dermatol 118, 869-874
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)