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Science 26 August 1977:
Vol. 197. no. 4306, pp. 912 - 914
DOI: 10.1126/science.887932
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Articles

Science, Vol 197, Issue 4306, 912-914
Copyright © 1977 by American Association for the Advancement of Science

articles

Synaptic mechanism of pentylenetetrazole: selectivity for chloride conductance

TC Pellmar and WA Wilson

In the neurons of Aplysia californica pentylenetetrazole (2 millimolar) greatly reduced chloride-dependent responses to the iontophoresis of putative transmitters. At the same concentration, pentylenetetrazole caused less attenuation of the other iontophoretic responses and had minimal membrane effects. Several convulsants have been observed to have a similar selectivity for the chloride conductance. A common mechanism of convulsant action--reduction of transmitter-induced chloride conductances--is hypothesized.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)