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Science 26 August 1977:
Vol. 197. no. 4306, pp. 910 - 911
DOI: 10.1126/science.887931
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Articles

Science, Vol 197, Issue 4306, 910-911
Copyright © 1977 by American Association for the Advancement of Science

articles

Alcohol tolerance in a cholinergic nerve terminal: relation to the membrane expansion-fluidization theory of ethanol action

M Curran and P Seeman

Phrenic nerve terminals from rats subjected to long-term ethanol treatment were more resistant to ethanol (in vitro) than terminals from sucrose-fed rats, as measured by the effect of ethanol on the frequency of miniature end plate potentials. Long-term ethanol exposure may thus induce the synthesis of more rigid membrane lipids, reducing membrane "fluidizability". This may provide a neurocellular basis for ethanol tolerance and cross-tolerance with anesthetics and barbiturates.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.
H Rottenberg, A Waring, and E Rubin (1981)
Science 213, 583-585
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