Science 26 August 1977: Vol. 197. no. 4306, pp. 893 - 895 DOI: 10.1126/science.887927

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Translating the Metastasis Paradigm from Scientific Theory to Clinical Oncology.

F. Dong, A. S. Budhu, and X. W. Wang (2009)
Clin. Cancer Res. 15, 2588-2593
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Cell Lineage Analysis of a Mouse Tumor.

D. Frumkin, A. Wasserstrom, S. Itzkovitz, T. Stern, A. Harmelin, R. Eilam, G. Rechavi, and E. Shapiro (2008)
Cancer Res. 68, 5924-5931
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Clinical Significance of CXC Chemokine Receptor-4 and c-Met in Childhood Rhabdomyosarcoma.

F. Diomedi-Camassei, H. P. McDowell, M. A. De Ioris, S. Uccini, P. Altavista, G. Raschella, R. Vitali, O. Mannarino, L. De Sio, D. A. Cozzi, et al. (2008)
Clin. Cancer Res. 14, 4119-4127
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Molecular Imaging of Metastatic Potential.

P. T. Winnard Jr., A. P. Pathak, S. Dhara, S. Y. Cho, V. Raman, and M. G. Pomper (2008)
J. Nucl. Med. 49, 96S-112S
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Comparisons of Metastases in Different Organs: Biological and Clinical Implications.

D. Tarin (2008)
Clin. Cancer Res. 14, 1923-1925
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In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States.

K. S. Hoek, O. M. Eichhoff, N. C. Schlegel, U. Dobbeling, N. Kobert, L. Schaerer, S. Hemmi, and R. Dummer (2008)
Cancer Res. 68, 650-656
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Aberrant Expression of Connexin 26 Is Associated with Lung Metastasis of Colorectal Cancer.

K. Ezumi, H. Yamamoto, K. Murata, M. Higashiyama, B. Damdinsuren, Y. Nakamura, N. Kyo, J. Okami, C. Y. Ngan, I. Takemasa, et al. (2008)
Clin. Cancer Res. 14, 677-684
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Yin-Yang Activities and Vicious Cycles in the Tumor Microenvironment.

I. P. Witz (2008)
Cancer Res. 68, 9-13
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Clonal Selection of Metastasis within the Life History of a Tumor.

J. E. Talmadge (2007)
Cancer Res. 67, 11471-11475
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Estrogen Insensitivity in a Model of Estrogen Receptor Positive Breast Cancer Lymph Node Metastasis.

J. C. Harrell, W. W. Dye, D. M.E. Harvell, M. Pinto, P. Jedlicka, C. A. Sartorius, and K. B. Horwitz (2007)
Cancer Res. 67, 10582-10591
 |  Abstract »  |  Full Text »  |  PDF »

Osteoactivin Promotes Breast Cancer Metastasis to Bone.

A. A.N. Rose, F. Pepin, C. Russo, J. E. Abou Khalil, M. Hallett, and P. M. Siegel (2007)
Mol. Cancer Res. 5, 1001-1014
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Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis.

R. R. Langley and I. J. Fidler (2007)
Endocr. Rev. 28, 297-321
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Collagen XXIII Expression Is Associated with Prostate Cancer Recurrence and Distant Metastases.

J. Banyard, L. Bao, M. D. Hofer, D. Zurakowski, K. A. Spivey, A. S. Feldman, L. M. Hutchinson, R. Kuefer, M. A. Rubin, and B. R. Zetter (2007)
Clin. Cancer Res. 13, 2634-2642
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of Human Colon Cancer Cell Lines from Fresh Tumors versus Xenografts: Comparison of Success Rate and Cell Line Features.

V. Dangles-Marie, M. Pocard, S. Richon, L.-B. Weiswald, F. Assayag, P. Saulnier, J.-G. Judde, J.-L. Janneau, N. Auger, P. Validire, et al. (2007)
Cancer Res. 67, 398-407
 |  Abstract »  |  Full Text »  |  PDF »

Clonal and Parallel Evolution of Primary Lung Cancers and Their Metastases Revealed by Molecular Dissection of Cancer Cells.

K. Takahashi, T. Kohno, S. Matsumoto, Y. Nakanishi, Y. Arai, S. Yamamoto, T. Fujiwara, N. Tanaka, and J. Yokota (2007)
Clin. Cancer Res. 13, 111-120
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Maintenance of Head and Neck Tumor Gene Expression Profiles upon Lymph Node Metastasis.

P. Roepman, A. de Jager, M. J.A. Groot Koerkamp, J. A. Kummer, P. J. Slootweg, and F. C.P. Holstege (2006)
Cancer Res. 66, 11110-11114
 |  Abstract »  |  Full Text »  |  PDF »

Preparing the "Soil": The Primary Tumor Induces Vasculature Reorganization in the Sentinel Lymph Node before the Arrival of Metastatic Cancer Cells.

C.-N. Qian, B. Berghuis, G. Tsarfaty, M. Bruch, E. J. Kort, J. Ditlev, I. Tsarfaty, E. Hudson, D. G. Jackson, D. Petillo, et al. (2006)
Cancer Res. 66, 10365-10376
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Derived Reactive Oxygen Species in the Acquisition of Metastatic Ability of Tumor Cells.

F. Okada, M. Kobayashi, H. Tanaka, T. Kobayashi, H. Tazawa, Y. Iuchi, K. Onuma, M. Hosokawa, M. C. Dinauer, and N. H. Hunt (2006)
Am. J. Pathol. 169, 294-302
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Tumor {beta}-1,4-Galactosyltransferase IV Overexpression Is Closely Associated with Colorectal Cancer Metastasis and Poor Prognosis.

W.-S. Chen, H.-Y. Chang, C.-P. Li, J. M. Liu, and T.-S. Huang (2005)
Clin. Cancer Res. 11, 8615-8622
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Repressor Slug Promotes Carcinoma Invasion and Predicts Outcome of Patients with Lung Adenocarcinoma.

J.-Y. Shih, M.-F. Tsai, T.-H. Chang, Y.-L. Chang, A. Yuan, C.-J. Yu, S.-B. Lin, G.-Y. Liou, M.-L. Lee, J. J.W. Chen, et al. (2005)
Clin. Cancer Res. 11, 8070-8078
 |  Abstract »  |  Full Text »  |  PDF »

Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.

E. H. van der Horst, Y. Y. Degenhardt, A. Strelow, A. Slavin, L. Chinn, J. Orf, M. Rong, S. Li, L.-H. See, K. Q. C. Nguyen, et al. (2005)
PNAS 102, 15901-15906
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer.

B. Weigelt, Z. Hu, X. He, C. Livasy, L. A. Carey, M. G. Ewend, A. M. Glas, C. M. Perou, and L. J. van't Veer (2005)
Cancer Res. 65, 9155-9158
 |  Abstract »  |  Full Text »  |  PDF »

Expression Profiling of Primary Tumors and Matched Lymphatic and Lung Metastases in a Xenogeneic Breast Cancer Model.

V. Montel, T.-Y. Huang, E. Mose, K. Pestonjamasp, and D. Tarin (2005)
Am. J. Pathol. 166, 1565-1579
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Circulating and Disseminated Tumor Cells.

S. Braun and B. Naume (2005)
J. Clin. Oncol. 23, 1623-1626
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Modeling metastasis in vivo.

C. Khanna and K. Hunter (2005)
Carcinogenesis 26, 513-523
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Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors.

W. Wang, S. Goswami, K. Lapidus, A. L. Wells, J. B. Wyckoff, E. Sahai, R. H. Singer, J. E. Segall, and J. S. Condeelis (2004)
Cancer Res. 64, 8585-8594
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Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q.

L. McArdle, M. McDermott, R. Purcell, D. Grehan, A. O'Meara, F. Breatnach, D. Catchpoole, A. C. Culhane, I. Jeffery, W. M. Gallagher, et al. (2004)
Carcinogenesis 25, 1599-1609
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Metastatic cancer DNA phenotype identified in normal tissues surrounding metastasizing prostate carcinomas.

D. C. Malins, N. K. Gilman, V. M. Green, T. M. Wheeler, E. A. Barker, M. A. Vinson, M. Sayeeduddin, K. E. Hellstrom, and K. M. Anderson (2004)
PNAS 101, 11428-11431
 |  Abstract »  |  Full Text »  |  PDF »

Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes.

K. Kawada, M. Sonoshita, H. Sakashita, A. Takabayashi, Y. Yamaoka, T. Manabe, K. Inaba, N. Minato, M. Oshima, and M. M. Taketo (2004)
Cancer Res. 64, 4010-4017
 |  Abstract »  |  Full Text »  |  PDF »

Genomic Profiling of Viable and Proliferative Micrometastatic Cells from Early-Stage Breast Cancer Patients.

R. Gangnus, S. Langer, E. Breit, K. Pantel, and M. R. Speicher (2004)
Clin. Cancer Res. 10, 3457-3464
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Brain metastases in melanoma: Roles of neurotrophins.

Y. Denkins, J. Reiland, M. Roy, N. D. Sinnappah-Kang, J. Galjour, B. P. Murry, J. Blust, R. Aucoin, and D. Marchetti (2004)
Neuro-oncol 6, 154-165
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Gene expression profiles of primary breast tumors maintained in distant metastases.

B. Weigelt, A. M. Glas, L. F. A. Wessels, A. T. Witteveen, J. L. Peterse, and L. J. van't Veer (2003)
PNAS 100, 15901-15905
 |  Abstract »  |  Full Text »  |  PDF »

Determination of Clonality of Metastasis by Cell-Specific Color-Coded Fluorescent-Protein Imaging.

N. Yamamoto, M. Yang, P. Jiang, M. Xu, H. Tsuchiya, K. Tomita, A. R. Moossa, and R. M. Hoffman (2003)
Cancer Res. 63, 7785-7790
 |  Abstract »  |  Full Text »  |  PDF »

Fully Human Antibodies to MCAM/MUC18 Inhibit Tumor Growth and Metastasis of Human Melanoma.

L. Mills, C. Tellez, S. Huang, C. Baker, M. McCarty, L. Green, J. M. Gudas, X. Feng, and M. Bar-Eli (2002)
Cancer Res. 62, 5106-5114
 |  Abstract »  |  Full Text »  |  PDF »

Usefulness of Analytical CEA Doubling Time and Half-life Time for Overlooked Synchronous Metastases in Colorectal Carcinoma.

K. Ito, K. Hibi, H. Ando, K. Hidemura, T. Yamazaki, S. Akiyama, and A. Nakao (2002)
Jpn. J. Clin. Oncol. 32, 54-58
 |  Abstract »  |  Full Text »  |  PDF »

Contrasting Expression of Thrombospondin-1 and Osteopontin Correlates with Absence or Presence of Metastatic Phenotype in an Isogenic Model of Spontaneous Human Breast Cancer Metastasis.

V. Urquidi, D. Sloan, K. Kawai, D. Agarwal, A. C. Woodman, D. Tarin, and S. Goodison (2002)
Clin. Cancer Res. 8, 61-74
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Collapsin Response Mediator Protein-1 and the Invasion and Metastasis of Cancer Cells.

J.-Y. Shih, S.-C. Yang, T.-M. Hong, A. Yuan, J. J. W. Chen, C.-J. Yu, Y.-L. Chang, Y.-C. Lee, K. Peck, C.-W. Wu, et al. (2001)
J Natl Cancer Inst 93, 1392-1400
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Neoplastic Angiogenesis.

I. J. Fidler (2000)
J Natl Cancer Inst Monographs 2000, 10-14
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Vascular Endothelial Growth Factor Is Necessary but not Sufficient for Production and Growth of Brain Metastasis.

S. Yano, H. Shinohara, R. S. Herbst, H. Kuniyasu, C. D. Bucana, L. M. Ellis, D. W. Davis, D. J. McConkey, and I. J. Fidler (2000)
Cancer Res. 60, 4959-4967
 |  Abstract »  |  Full Text »

A Spontaneous Murine Melanoma Lung Metastasis Comprised of Host Tumor Hybrids.

A. K. Chakraborty, S. Sodi, M. Rachkovsky, N. Kolesnikova, J. T. Platt, J. L. Bolognia, and J. M. Pawelek (2000)
Cancer Res. 60, 2512-2519
 |  Abstract »  |  Full Text »

Differential Expression of E-cadherin and Type IV Collagenase Genes Predicts Outcome in Patients with Stage I Non-Small Cell Lung Carcinoma.

R. S. Herbst, S. Yano, H. Kuniyasu, F. R. Khuri, C. D. Bucana, F. Guo, D. Liu, B. Kemp, J. J. Lee, W. K. Hong, et al. (2000)
Clin. Cancer Res. 6, 790-797
 |  Abstract »  |  Full Text »

Relative Expression of E-Cadherin and Type IV Collagenase Genes Predicts Disease Outcome in Patients with Resectable Pancreatic Carcinoma.

H. Kuniyasu, L. M. Ellis, D. B. Evans, J. L. Abbruzzese, C. J. Fenoglio, C. D. Bucana, K. R. Cleary, E. Tahara, and I. J. Fidler (1999)
Clin. Cancer Res. 5, 25-33
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic Significance of PCNA Expression in Laryngeal Cancer.

S. Sarac, A. Ayhan, A. S. Hosal, and S. Kaya (1998)
Arch Otolaryngol Head Neck Surg 124, 1321-1324
 |  Abstract »  |  Full Text »  |  PDF »

Loss of AP-2 Results in Up-regulation of MCAM/MUC18 and an Increase in Tumor Growth and Metastasis of Human Melanoma Cells.

D. Jean, J. E. Gershenwald, S. Huang, M. Luca, M. J. Hudson, M. A. Tainsky, and M. Bar-Eli (1998)
J. Biol. Chem. 273, 16501-16508
 |  Abstract »  |  Full Text »  |  PDF »

Selection of Invasive and Metastatic Subpopulations from a Human Lung Adenocarcinoma Cell Line.

Y.-W. Chu, P.-C. Yang, S.-C. Yang, Y.-C. Shyu, M. J. C. Hendrix, R. Wu, and C.-W. Wu (1997)
Am. J. Respir. Cell Mol. Biol. 17, 353-360
 |  Abstract »  |  Full Text »

Metastatic Potential of Colon Carcinoma: Expression of ABO/Lewis-Related Antigens.

S. D. Hoff, T. Irimura, Y. Matsushita, D. M. Ota, K. R. Cleary, and S.-i. Hakomori (1990)
Arch Surg 125, 206-209
 |  Abstract »  |  PDF »

In Vitro Killing of Melanoma by Liposome-Delivered Intracellular Irradiation.

S. S. Pikul II, N. J. Parks, and P. D. Schneider (1987)
Arch Surg 122, 1417-1420
 |  Abstract »  |  PDF »

Modulation of the metastatic activity of melanoma cells by laminin and fibronectin.

V. Terranova, J. Williams, L. Liotta, and G. Martin (1984)
Science 226, 982-985
 |  Abstract »  |  PDF »

Heterogeneity of Human Metastatic Clones by In Vitro Chemosensitivity Testing: Implications for the Clinical Application of the Clonogenic Assay.

C. A. Bertelsen, E. I. Korn, D. L. Morton, and D. H. Kern (1983)
Arch Surg 118, 1406-1409
 |  Abstract »  |  PDF »

Biological diversity in metastatic neoplasms: origins and implications.

I. Fidler and I. Hart (1982)
Science 217, 998-1003
 |  Abstract »  |  PDF »

Evidence for the clonal origin of spontaneous metastases.

J. Talmadge, Wolman SR, and I. Fidler (1982)
Science 217, 361-363
 |  Abstract »  |  PDF »

In Vitro Characteristics of Uveal Malignant Melanomas.

N. T. Felberg, T. Mione, J. A. Shields, and J. L. Federman (1982)
Arch Ophthalmol 100, 987-990
 |  Abstract »  |  PDF »

Tumor metastasis is not due to adaptation of cells to a new organ environment.

G. Nicolson and S. Custead (1982)
Science 215, 176-178
 |  Abstract »  |  PDF »

Choroidal Melanoma.

I. W. McLean, W. D. Foster, and L. E. Zimmerman (1980)
Arch Ophthalmol 98, 1298-1301
 |  Abstract »  |  PDF »

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