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Science 19 August 1977:
Vol. 197. no. 4305, pp. 776 - 778
DOI: 10.1126/science.302030
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Articles

Science, Vol 197, Issue 4305, 776-778
Copyright © 1977 by American Association for the Advancement of Science

articles

Control of a cell surface major glycoprotein by epidermal growth factor

LB Chen, RC Gudor, TT Sun, AB Chen, and MW Mosesson

When the serum concentration of the culture medium is below 0.7 per-cent, 3T3 mouse cells lose most of their large external transformation sensitive (LETS) protein at the cell surface, Subsequent addition of epidermal growth factor results in the reappearance of massive fibrillar LETS protein networks on the surface of conluent 3T3 cells. Thirteen other hormones tested do not have this effect. It appears that epidermal growth factor can control the expression of LETS protein.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters.
H. Elsholtz, H. Mangalam, E Potter, V. Albert, S Supowit, R. Evans, and M. Rosenfeld (1986)
Science 234, 1552-1557
   Abstract »    PDF »
LETS Protein in Normal and Pathological Human Oral Epithelium.
B.R. Zetter, T.E. Daniels, C. Quadra-White, and J.S. Greenspan (1979)
Journal of Dental Research 58, 484-488
   Abstract »    PDF »


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