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Science 19 August 1977:
Vol. 197. no. 4305, pp. 769 - 771
DOI: 10.1126/science.70075
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Articles

Science, Vol 197, Issue 4305, 769-771
Copyright © 1977 by American Association for the Advancement of Science

articles

HLA variants of cultured human lymphoid cells: evidence for mutational origin and estimation of mutation rate

D Pious and C Soderland

Variants of a diploid lymphoid cell line that show a loss of HLA-B27 antigen occur randomly in time and independently of exposure to the alloantiserum used for their isolation. From these and previous findings of variant stability, inducibility by mutagens, and the absence of linked variation, we colclude that most HLA variants arise by mutation. The mutation rate for HLA-B27 loss is 8 x 10(-7) per cell per generation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)