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Science 12 August 1977:
Vol. 197. no. 4304, pp. 674 - 676
DOI: 10.1126/science.877584
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Articles

Science, Vol 197, Issue 4304, 674-676
Copyright © 1977 by American Association for the Advancement of Science

articles

Interferon: an inducer of macrophage activation by polyanions

RM Schultz, JD Papamatheakis, and MA Chirigos

Purified mouse fibroblast interferon (IF) directly rendered resting macrophages tumoricidal. The physicochemical properties and species specificity of the stimulatory agent fall within the present definition of IF. Since a number of polyanions induce macrophage IF, the antitumor and antimicrobial activities may result from the ability of newly released IF to modify macrophage activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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L. E. Ronnblom, G. V. Alm, and K. E. Oberg (1991)
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Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.
P. Sunkara, N. Prakash, G. Mayer, and A Sjoerdsma (1983)
Science 219, 851-853
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Clinical and Immunologic Effects of Recombinant Leukocyte A Interferon in Eight Patients With Advanced Cancer.
S. J. Horning, J. F. Levine, R. A. Miller, S. A. Rosenberg, and T. C. Merigan (1982)
JAMA 247, 1718-1722
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Interferons: Rationale for Clinical Trials in Neoplastic Disease.
E. C. BORDEN (1979)
Ann Intern Med 91, 472-479
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Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series.
R. Schultz, N. Pavlidis, W. Stylos, and M. Chirigos (1978)
Science 202, 320-321
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