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Science 12 August 1977:
Vol. 197. no. 4304, pp. 670 - 671
DOI: 10.1126/science.877582
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Articles

Science, Vol 197, Issue 4304, 670-671
Copyright © 1977 by American Association for the Advancement of Science

articles

Structure of a molluscan cardioexcitatory neuropeptide

DA Price and MJ Greenberg

A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide amide Phe-Met-Arg-Phe-NH2. Its structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis. This neuropeptide is active at about 10(-8)M when assayed on molluscan muscle.


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