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Science 12 August 1977:
Vol. 197. no. 4304, pp. 661 - 663
DOI: 10.1126/science.877579
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Articles

Science, Vol 197, Issue 4304, 661-663
Copyright © 1977 by American Association for the Advancement of Science

articles

Hydrodynamic evidence in support of spacer regions in chromatin

KS Schmitz and BR Shaw

Quasi-elastic light scattering and sedimentation velocity methods were used to study the hydrodynamic properties of purified dimer subunits obtained from partial digestion of chicken erythrocyte chromatin with staphylococcal nuclease. The experimental value of 1.87 +/- 0.08 X 10(-7) gram per second for the friction factor of these dimer subunits in low ionic strength buffer cannot be reasonably interpreted in terms of a contiguous sphere model. Analysis by means of an equivalent dimer method suggests that the spacer region accounts for a maximum of 19 percent of the friction properties of the dimer.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)