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Science 12 August 1977:
Vol. 197. no. 4304, pp. 657 - 659
DOI: 10.1126/science.877577
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Articles

Science, Vol 197, Issue 4304, 657-659
Copyright © 1977 by American Association for the Advancement of Science

articles

Catechol estrogens: presence in brain and endocrine tissues

SM Paul and J Axelrod

Catechol estrogens have been identified and measured in rat brain and various endocrine tissues with the use of a sensitive radioenzymatic assay. The specificity of this assay was confirmed by thin-layer chromatography and mass spectral analysis of the reaction products. The concentration of catechol estrogens in the hypothalamus and pituitary are at least ten times higher than reported previously for the parent estrogens. Catechol estrogens have potent endocrine effects and, because of their normal occurrence in the hypothalamic-pituitary axis, they have an important role in neuroendocrine regulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Novel Mechanism for Adenylyl Cyclase Inhibition from the Crystal Structure of Its Complex with Catechol Estrogen.
C. Steegborn, T. N. Litvin, K. C. Hess, A. B. Capper, R. Taussig, J. Buck, L. R. Levin, and H. Wu (2005)
J. Biol. Chem. 280, 31754-31759
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Science. ISSN 0036-8075 (print), 1095-9203 (online)