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Science 5 August 1977:
Vol. 197. no. 4303, pp. 559 - 561
DOI: 10.1126/science.267327
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Articles

Science, Vol 197, Issue 4303, 559-561
Copyright © 1977 by American Association for the Advancement of Science

articles

Inducibility of transferrin receptors on friend erythroleukemic cells

HY Hu, J Gardner, and P Aisen

The ability of Friend erythroleukemic cells to bind transferrin and take up its iron increases substantially as a result of dimethyl sulfoxide-stimulated differentiation. Although transferrin-binding activity is also demonstrable in another mouse cell line of hematopoietic origin, the lymphoma cell, it does not increase on exposure to dimethyl sulfoxide. Gel filtration studies corroborate that the binding of transferrin to the erythroleukemic cells is due to the formation of a specific complex of transferrin and a membrane receptor. Thus, the specific interaction of transferrin with its receptor is another expression of dimethyl sulfoxide-induced differentiation in the Friend cell.


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