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Science 29 July 1977:
Vol. 197. no. 4302, pp. 469 - 470
DOI: 10.1126/science.406673
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Articles

Science, Vol 197, Issue 4302, 469-470
Copyright © 1977 by American Association for the Advancement of Science

articles

Bacteriophages in live virus vaccines: lack of evidence for effects on the genome of rhesus monkeys

JB Milstien, Walker JR, and JC Petricciani

Four juvenile rhesus monkeys were inoculated with 10(12) plaque-forming units of the bacteriophage phiV1 isolated from live virus vaccines. After phiV1 had been cleared from the blood, DNA's were isolated from the livers and kidneys and analyzed for the presence of bacteriophage by plaque assays, and for the presence of phiV1 DNA by DNA-DNA reassociation kinetics. No evidence was found for persistence of the bacteriophage or for replication of the phage genome in these rhesus monkeys.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)