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Science 29 July 1977:
Vol. 197. no. 4302, pp. 468 - 469
DOI: 10.1126/science.877570
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Articles

Science, Vol 197, Issue 4302, 468-469
Copyright © 1977 by American Association for the Advancement of Science

articles

L-dopa: selective toxicity for melanoma cells in vitro

MM Wick, L Byers, and E Frei 3rd

In a study of the effect of L-dopa, an intermediate in the biosynthesis of the pigment melanin, on the growth of human and murine melanoma cells a highly selective inhibition of growth was observed for pigmented cell lines (S91A and human melanoma) as compared to the nonpigmented control cells (amelanotic melanoma S91B, mouse fibroblast L929, and Chinese hamster ovary). There was a correlation between toxicity and the extent of incorporation of radioactively labeled L-dopa by each line.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Levodopa Administration and Multiple Primary Cutaneous Melanomas.
J. E. Bernstein, M. Medenica, K. Soltani, A. Solomon, and A. L. Lorincz (1980)
Arch Dermatol 116, 1041-1044
   Abstract »    PDF »
L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment.
M. Wick (1978)
Science 199, 775-776
   Abstract »    PDF »


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