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Science 22 July 1977:
Vol. 197. no. 4301, pp. 393 - 396
DOI: 10.1126/science.877564
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Articles

Science, Vol 197, Issue 4301, 393-396
Copyright © 1977 by American Association for the Advancement of Science

articles

Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats

IM Faust, PR Johnson, and J Hirsch

Lipectomized and sham-operated rats were fed a high-fat diet to induce hyperphagia and rapid fat accumulation. Lipectomized rats with 25% fewer adipocytes were less hyperphagic and accumulated less fat, but their adipocytes remained equal in size to adipocytes of controls. A role for adipocyte size in fat storage regulation and food intake control is postulated.


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