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Science 22 July 1977:
Vol. 197. no. 4301, pp. 388 - 389
DOI: 10.1126/science.406671
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Articles

Science, Vol 197, Issue 4301, 388-389
Copyright © 1977 by American Association for the Advancement of Science

articles

An effective immunization of experimental monkeys against a human malaria parasite, Plasmodium falciparum

WA Siddiqui

This is the first report of successful immunization of experimental monkeys against a human malaria parasite, Plasmodium falciparum. Of the five owl monkeys (Aotus trivirgatus) used in this pilot study, two served as controls and the other three were immunized with P. falciparum antigen consisting primarily of mature segmenters containing fully developed merozoites. Two injections of antigen emulsified with Freund's complete adjuvant were administered intramuscularly 3 weeks apart. Three weeks after the second vaccination, all monkeys were challenged with the homologous strain of P. falciparum. The control monkeys died with high levels of parasitemia within 2 weeks of challenge. The three immunized monkeys survived and showed strong protection against P. falciparum. These results are encouraging for the possible future development of an effective vaccine against human malaria.


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