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Science 22 July 1977:
Vol. 197. no. 4301, pp. 376 - 378
DOI: 10.1126/science.195339
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Articles

Science, Vol 197, Issue 4301, 376-378
Copyright © 1977 by American Association for the Advancement of Science

articles

Antigenic shift of visna virus in persistently infected sheep

O Narayan, DE Griffin, and J Chase

Visna viruses isolated from persistently infected sheep were antigenically distinct from the plaque-purified virus used for inoculation. The selection of antigenic variants under antibody pressure, thought to occur in vivo, was reproduced in sheep cell cultures inoculated with plaque-purified visna virus and maintained in antibody. Antigenic shift may be a mechanism for persistence of virus in slow or recurrent viral infections.


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Rapid evolution of RNA genomes.
J Holland, K Spindler, F Horodyski, E Grabau, S Nichol, and S VandePol (1982)
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