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Science 15 July 1977:
Vol. 197. no. 4300, pp. 289 - 291
DOI: 10.1126/science.877555
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Articles

Science, Vol 197, Issue 4300, 289-291
Copyright © 1977 by American Association for the Advancement of Science

articles

Fatty acids and their prostaglandin derivatives: inhibitors of proliferation in aortic smooth muscle cells

JJ Huttner, ET Gwebu, RV Panganamala, GE Milo, DC Cornwell, HM Sharma, and JC Geer

Prostaglandins are synthesized from eicosa-8,11,14-trienoic acid and eicosa-5,8,11-14-tetraenoic acid by smooth muscle cell cultures from guinea pig aorta. Production is inhibited by indomethacin. The precursor fatty acids and their prostaglandin derivatives inhibit proliferation of the cell cultures. The relative availability of fatty acids for prostaglandin biosynthesis may represent a control mechanism for cell proliferation.


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