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Science 15 July 1977:
Vol. 197. no. 4300, pp. 282 - 285
DOI: 10.1126/science.195338
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Articles

Science, Vol 197, Issue 4300, 282-285
Copyright © 1977 by American Association for the Advancement of Science

articles

Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid

HA Chapman Jr and JB Hibbs Jr

The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Macrophage tumor killing: influence of the local environment.
J. Hibbs Jr, R. Taintor, H. Chapman Jr, and J. Weinberg (1977)
Science 197, 279-282
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