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Science 15 July 1977:
Vol. 197. no. 4300, pp. 272 - 275
DOI: 10.1126/science.195337
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Articles

Science, Vol 197, Issue 4300, 272-275
Copyright © 1977 by American Association for the Advancement of Science

articles

Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression

YS Cho-Chung and BH Redler

Growth of mammary carcinoma induced by 7,12-dimethyl-benz(a) anthracene is arrested by either ovariectomy or treatment with N6,O2-dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP). When this occurs, a new nonhistone protein species becomes the predominant endogenous substrate of cyclic AMP-dependent protein kinase in the tumor nuclei. Phosphorylation of this regression-associated protein ceases when resumption of tumor growth is induced by either the injection of 17 beta-estradiol or cessation of dibutyryl cyclic AMP treatment. Thus phosphorylation of regression-associated protein may play a role in the regression of hormone-dependent mammary tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cyclic AMP receptor triggers nuclear protein phosphorylation in a hormone-dependent mammary tumor cell-free system.
Y. Cho-Chung, D Archibald, and T Clair (1979)
Science 205, 1390-1392
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Science. ISSN 0036-8075 (print), 1095-9203 (online)