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Science 15 July 1977:
Vol. 197. no. 4300, pp. 265 - 266
DOI: 10.1126/science.877551
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Articles

Science, Vol 197, Issue 4300, 265-266
Copyright © 1977 by American Association for the Advancement of Science

articles

Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium

GR Sutherland

The observation of heritable fragile sites on human chromosomes prepared for lymphocyte cultures has been shown to depend on the type of tissue culture medium in which the lymphocytes are grown. The sites are observed at a much greater frequency when medium 199 is used than when RPMI 1640, Ham's F10, Eagle's (basal), and CMRL 1969 are used. One site on the X chromosome is of clinical significance in that it is a marker for X-linked mental retardation.


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