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Science 15 July 1977:
Vol. 197. no. 4300, pp. 263 - 265
DOI: 10.1126/science.327545
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Articles

Science, Vol 197, Issue 4300, 263-265
Copyright © 1977 by American Association for the Advancement of Science

articles

A bactericidal effect for human lactoferrin

RR Arnold, MF Cole, and McGhee JR

Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stimulus-Dependent Impairment of the Neutrophil Oxidative Burst Response in Lactoferrin-Deficient Mice.
P. P. Ward, M. Mendoza-Meneses, P. W. Park, and O. M. Conneely (2008)
Am. J. Pathol. 172, 1019-1029
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Factors Affecting the Lactoferrin Concentration in Bovine Milk.
J. B. Cheng, J. Q. Wang, D. P. Bu, G. L. Liu, C. G. Zhang, H. Y. Wei, L. Y. Zhou, and J. Z. Wang (2008)
J Dairy Sci 91, 970-976
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Broad Up-Regulation of Innate Defense Factors during Acute Cholera.
C.-F. Flach, F. Qadri, T. R. Bhuiyan, N. H. Alam, E. Jennische, I. Lonnroth, and J. Holmgren (2007)
Infect. Immun. 75, 2343-2350
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Human Lactoferricin Is Partially Folded in Aqueous Solution and Is Better Stabilized in a Membrane Mimetic Solvent.
H. N. Hunter, A. R. Demcoe, H. Jenssen, T. J. Gutteberg, and H. J. Vogel (2005)
Antimicrob. Agents Chemother. 49, 3387-3395
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Structural Origin of Endotoxin Neutralization and Antimicrobial Activity of a Lactoferrin-based Peptide.
B. Japelj, P. Pristovsek, A. Majerle, and R. Jerala (2005)
J. Biol. Chem. 280, 16955-16961
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Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes.
O. Levy (2004)
J. Leukoc. Biol. 76, 909-925
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Nomenclature of the Proteins of Cows' Milk--Sixth Revision.
H. M. Farrell Jr., R. Jimenez-Flores, G. T. Bleck, E. M. Brown, J. E. Butler, L. K. Creamer, C. L. Hicks, C. M. Hollar, K. F. Ng-Kwai-Hang, and H. E. Swaisgood (2004)
J Dairy Sci 87, 1641-1674
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Modulation of In Vitro Fungicidal Activity of Human Lactoferrin against Candida albicans by Extracellular Cation Concentration and Target Cell Metabolic Activity.
M. Viejo-Diaz, M. T. Andres, and J. F. Fierro (2004)
Antimicrob. Agents Chemother. 48, 1242-1248
   Abstract »    Full Text »    PDF »
Antimicrobial polypeptides.
T. Ganz (2004)
J. Leukoc. Biol. 75, 34-38
   Abstract »    Full Text »    PDF »
One of Two Human Lactoferrin Variants Exhibits Increased Antibacterial and Transcriptional Activation Activities and Is Associated with Localized Juvenile Periodontitis.
K. Velliyagounder, J. B. Kaplan, D. Furgang, D. Legarda, G. Diamond, R. E. Parkin, and D. H. Fine (2003)
Infect. Immun. 71, 6141-6147
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Lactoferrin Impairs Type III Secretory System Function in Enteropathogenic Escherichia coli.
T. J. Ochoa, M. Noguera-Obenza, F. Ebel, C. A. Guzman, H. F. Gomez, and T. G. Cleary (2003)
Infect. Immun. 71, 5149-5155
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Potential host-defense role of a human milk vitamin B-12-binding protein, haptocorrin, in the gastrointestinal tract of breastfed infants, as assessed with porcine haptocorrin in vitro.
Y. Adkins and B. Lonnerdal (2003)
Am. J. Clinical Nutrition 77, 1234-1240
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Enhancement of antibacterial and lipopolysaccharide binding activities of a human lactoferrin peptide fragment by the addition of acyl chain.
A. Majerle, J. Kidric, and R. Jerala (2003)
J. Antimicrob. Chemother. 51, 1159-1165
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Gene Expression of Immunologically Important Factors in Blood Cells, Milk Cells, and Mammary Tissue of Cows.
M. W. Pfaffl, S. L. Wittmann, H. H. D. Meyer, and R. M. Bruckmaier (2003)
J Dairy Sci 86, 538-545
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Both Family 1 and Family 2 PspA Proteins Can Inhibit Complement Deposition and Confer Virulence to a Capsular Serotype 3 Strain of Streptococcus pneumoniae.
B. Ren, A. J. Szalai, O. Thomas, S. K. Hollingshead, and D. E. Briles (2003)
Infect. Immun. 71, 75-85
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Review: Antimicrobial and immunoregulatory functions of lactoferrin and its potential therapeutic application.
D. Caccavo, N. M. Pellegrino, M. Altamura, A. Rigon, L. Amati, A. Amoroso, and E. Jirillo (2002)
Innate Immunity 8, 403-417
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Lactoferrin Protects Rabbits from Shigella flexneri-Induced Inflammatory Enteritis.
H. F. Gomez, T. J. Ochoa, I. Herrera-Insua, L. G. Carlin, and T. G. Cleary (2002)
Infect. Immun. 70, 7050-7053
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Peptides From the N-terminal End of Bovine Lactoferrin Induce Apoptosis in Human Leukemic (HL-60) Cells.
M. K. Roy, Y. Kuwabara, K. Hara, Y. Watanabe, and Y. Tamai (2002)
J Dairy Sci 85, 2065-2074
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Immobilized Lactoferrin Is a Stimulus for Eosinophil Activation.
L. L. Thomas, W. Xu, and T. T. Ardon (2002)
J. Immunol. 169, 993-999
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Antiinflammatory Activities of Lactoferrin.
O. M. Conneely (2001)
J. Am. Coll. Nutr. 20, 389S-395
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Lactoferrin Binds CpG-Containing Oligonucleotides and Inhibits Their Immunostimulatory Effects on Human B Cells.
B. E. Britigan, T. S. Lewis, M. Waldschmidt, M. L. McCormick, and A. M. Krieg (2001)
J. Immunol. 167, 2921-2928
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Characterization of Binding of Human Lactoferrin to Pneumococcal Surface Protein A.
A. Hakansson, H. Roche, S. Mirza, L. S. McDaniel, A. Brooks-Walter, and D. E. Briles (2001)
Infect. Immun. 69, 3372-3381
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Crystal Structure of Hen Apo-ovotransferrin. BOTH LOBES ADOPT AN OPEN CONFORMATION UPON LOSS OF IRON.
H. Kurokawa, J. C. Dewan, B. Mikami, J. C. Sacchettini, and M. Hirose (1999)
J. Biol. Chem. 274, 28445-28452
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Lactoferrin-Lipid A-Lipopolysaccharide Interaction: Inhibition by Anti-Human Lactoferrin Monoclonal Antibody AGM 10.14.
D. Caccavo, A. Afeltra, S. Pece, G. Giuliani, M. Freudenberg, C. Galanos, and E. Jirillo (1999)
Infect. Immun. 67, 4668-4672
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Restricted Spatiotemporal Expression of Lactoferrin during Murine Embryonic Development.
P. P. Ward, M. Mendoza-Meneses, B. Mulac-Jericevic, G. A. Cunningham, O. Saucedo-Cardenas, C. T. Teng, and O. M. Conneely (1999)
Endocrinology 140, 1852-1860
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Structure-Function Relationship of Antibacterial Synthetic Peptides Homologous to a Helical Surface Region on Human Lactoferrin against Escherichia coli Serotype O111.
D. S. Chapple, D. J. Mason, C. L. Joannou, E. W. Odell, V. Gant, and R. W. Evans (1998)
Infect. Immun. 66, 2434-2440
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Characterization of Recombinant Human Lactoferrin Secreted in Milk of Transgenic Mice.
J. H. Nuijens, P. H.C. van Berkel, M. E.J. Geerts, P. P. Hartevelt, H. A. de Boer, H. A. van Veen, and F. R. Pieper (1997)
J. Biol. Chem. 272, 8802-8807
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Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.
P. D. Siebert and B. C. B. Huang (1997)
PNAS 94, 2198-2203
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Cooperative Interactions between the Amino- and Carboxyl-terminal Lobes Contribute to the Unique Iron-binding Stability of Lactoferrin.
P. P. Ward, X. Zhou, and O. M. Conneely (1996)
J. Biol. Chem. 271, 12790-12794
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Caries-Protective Factors in Saliva.
F. Lagerlof (1994)
Advances in Dental Research 8, 229-238
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Neutrophils and Host Defense.
R. I. Lehrer, T. Ganz, M. E. Selsted, B. M. Babior, and J. T. Curnutte (1988)
Ann Intern Med 109, 127-142
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Characterization of Lactoferrin Interaction with Streptococcus mutans.
M.O. Lassiter, A.L. Newsome, L.D. Sams, and R.R. Arnold (1987)
Journal of Dental Research 66, 480-485
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Anion-mediated Fe3+ Release Mechanism in Ovotransferrin C-lobe. A STRUCTURALLY IDENTIFIED SO42- BINDING SITE AND ITS IMPLICATIONS FOR THE KINETIC PATHWAY.
K. Mizutani, B. K. Muralidhara, H. Yamashita, S. Tabata, B. Mikami, and M. Hirose (2001)
J. Biol. Chem. 276, 35940-35946
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